THERAPEUTICS
Combined HRT increased CV events more than placebo but did not differ from oestrogen HRT after menopause
| The first 150 words of the full text of this article appear below. |
A H MacLennan
Dr A H MacLennan, University of Adelaide, Adelaide, South Australia, Australia; alastair.maclennan@adelaide.edu.au
STUDY DESIGN
randomised controlled trial (Women’s International Study of long Duration Oestrogen after Menopause [WISDOM]).
concealed.*
blinded ({patients, healthcare providers}
, and outcome assessors).*
384 general practices in the UK, 91 in Australia, and 24 in New Zealand.
STUDY QUESTION
5692 women, 50–69 years of age (mean age 63 y), who were postmenopausal and achieved 80% compliance during a 12-week run-in period. Exclusion criteria included previous breast cancer; cancer other than basal or squamous cell skin cancer within the past 10 years; endometriosis or endometrial hyperplasia; venous thromboembolism (VTE); current gall stones; and 
1 of the following within the past 6 months—myocardial infarction (MI), unstable angina, cerebrovascular accident, subarachnoid haemorrhage, transient ischaemic attack, or use of hormone replacement therapy (HRT) unless willing to discontinue before randomisation.
combined HRT (oral conjugated equine oestrogen, 0.625 mg daily, plus oral medroxyprogesterone acetate,
University of Toronto, Toronto, Ontario, Canada
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Menopause (including HRT)
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