AETIOLOGY
Glomerular filtration rate <45 ml/min/1.73 m2 with microalbuminuria was associated with increased CV death
| The first 150 words of the full text of this article appear below. |
Dr. S Hallan
Correspondence to: Dr. S Hallan, NTNU St. Olav University Hospital, Norway; stein.hallan@ntnu.no
STUDY QUESTION
Does estimated glomerular filtration rate (EGFR) combined with urine albumin excretion predict cardiovascular (CV) death?
STUDY DESIGN
cohort study (second Nord-Trøndelag Health Study [HUNT II]) with a median 8.3-year follow-up.
Nord-Trøndelag County, Norway.
9709 participants 
20 years of age (mean age 62 y, 55% women, 76% had hypertension or diabetes) who provided 3 urine samples. Analysis was stratified by age.
EGFR (75 ml/min/1.73 m2, 60–74 ml/min/1.73 m2, 45–59 ml/min/1.73 m2, or <45 ml/min/1.73 m2) and albuminuria (optimal urine albumin-creatinine ratio [ACR] [<5 mg/g in men; <7 mg/g in women], high-normal ACR [5–19 mg/g in men; 7–29 mg/g in women], or microalbuminuria [ACR 20–200 mg/g in men; 30–300 mg/g in women]). Results were adjusted for age, sex, CV disease, diabetes, systolic blood pressure, antihypertensive drugs, smoking, and total and high-density lipoprotein cholesterol.
CV
Tufts-New England Medical Center, Boston, Massachusetts, USA
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