DIAGNOSIS
A rapid antibody test had high specificity but low sensitivity for diagnosing coeliac disease
| The first 150 words of the full text of this article appear below. |
M Maki
Dr M Maki, Tampere University Hospital and Medical School, Tampere, Finland; markku.maki@uta.fi
STUDY QUESTION
Is a rapid antibody test accurate for diagnosing coeliac disease in children?
STUDY DESIGN
blinded comparison of a rapid IgA antibody test with combined IgA plus IgG antibody test and small bowel biopsy.
Jász-Nagykun-Szolnok county, Hungary.
2690 children, 6 years of age, who had a preschool physical examination.
the rapid antibody test detected IgA antibodies to tissue transglutaminase in whole blood from a finger prick (evaluated after 5 min). The combined antibody test detected IgA and IgG antibodies to endomysium and IgA antibodies to tissue transglutaminase from capillary blood.
biopsy samples of the small intestine were taken during upper gastrointestinal endoscopy from the distal part of the duodenum. The ratio of villous height to crypt depth was measured (ratio <1 = coeliac disease) by evaluators who were blinded.
sensitivity, specificity, and likelihood ratios.
MAIN RESULTS
37 (1.4%) children had coeliac
Mayo Clinic, Rochester, Minnesota, USA
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