THERAPEUTICS
Antihypertensive therapy with indapamide and perindopril reduced mortality in patients 
80 years
| The first 150 words of the full text of this article appear below. |
N S Beckett
Dr N S Beckett, Imperial College, London, UK; n.beckett@imperial.ac.uk
STUDY DESIGN
randomised placebo controlled trial (Hypertension in the Very Elderly Trial [HYVET]).
{concealed}*.
blinded (patients, clinicians, and outcome adjudication committee).
STUDY QUESTION
195 centres in Europe, China, Australasia, and Tunisia.
3845 patients 
80 years of age (mean age 84 y, 60% women) with persistent hypertension (mean sitting blood pressure [BP] 173/91 mm Hg). Exclusion criteria included accelerated or secondary hypertension, haemorrhagic stroke in the past 6 months, heart failure, gout, and dementia.
sustained-release indapamide, 1.5 mg/day, with perindopril, 2 or 4 mg/day, added if needed to reach targets of systolic BP <150 mm Hg and diastolic BP <80 mm Hg (n = 1933) or placebo (n = 1912).
stroke, heart failure, any cardiovascular event, and death from any cause, cardiovascular cause, cardiac cause, or stroke.
median 1.8 years.
99.6% (intention-to-treat analysis).
MAIN RESULTS
Antihypertensive treatment reduced risks of heart failure, any cardiovascular event,
Mount Sinai Medical Center, New York, New York, USA
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