THERAPEUTICS
Buflomedil reduced cardiovascular events in peripheral arterial disease
| The first 150 words of the full text of this article appear below. |
A Leizorovicz
Dr A Leizorovicz, Service de Pharmacologie Clinique, Lyon, France; al@upcl.univ-lyon1.fr
STUDY DESIGN
randomised placebo controlled trial (Limbs International Medicinal Buflomedil [LIMB]).
concealed.*
blinded (patients and outcome assessors).*
STUDY QUESTION
123 centres in the Czech Republic, France, Hungary, and Russia.
2078 patients who were 40–90 years of age (median age 61 y, 80% men) and had documented peripheral arterial obstructive disease (PAD) and an ankle-brachial index at rest >0.30 and 
0.80. Exclusion criteria were ischaemic rest pain, ulceration or gangrene, iliac or common femoral artery stenosis or occlusion, arterial occlusion of embolic origin, Buerger disease or any non-atherosclerotic arterial disease of the lower limb, any factor confounding evaluation of PAD or effect of study treatment, myocardial infarction (MI) or stroke in the past 45 days, vascular or endovascular surgery in the past 45 days or planned within the next month, active cancer, short life expectancy, thrombophilia, pregnancy, or breast-feeding.
buflomedil (n = 1043)
University of Western Ontario, London, Ontario, Canada
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