THERAPEUTICS
Risk of cancer was still increased over 2 years after stopping hormone therapy
| The first 150 words of the full text of this article appear below. |
G Heiss
Dr G Heiss, University of North Carolina School of Public Health, Chapel Hill, NC, USA; gerardo_heiss@unc.edu
STUDY DESIGN
randomised placebo-controlled trial (Women’s Health Initiative [WHI] trial).
{concealed}*.
blinded (participants, clinicians, {data collectors, outcome assessors, and safety committee}*).
STUDY QUESTION
40 clinical centres in the USA.
16 608 postmenopausal women 50–79 years of age with an intact uterus. 15 730 women (mean age 63 y) were included in the postintervention phase.
Conjugated equine oestrogen (CEO), 0.625 mg/day, plus medroxyprogesterone acetate (MPA), 2.5 mg/day (n = 8052), or placebo (n = 7678).
included all-cause mortality; cardiovascular (CV) events (coronary heart disease [CHD], revascularisation, stroke, and thromboembolism); cancer (invasive breast, endometrial, colorectal, and all); fractures; and a global index.
mean 2.4 years after stopping therapy.
95% (intention-to-treat analysis).
MAIN RESULTS
During the postintervention phase, the CEO plus MPA group had higher risk of all cancers than the placebo group (table). Groups did not differ for all-cause mortality,
University of Toronto, Toronto, Ontario, Canada
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Menopause (including HRT)
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Screening (oncology)
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Contraception
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Drugs: obstetrics and gynaecology
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Epidemiologic studies
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