THERAPEUTICS
Metformin plus a lifestyle intervention was more effective than either alone for antipsychotic-induced weight gain
| The first 150 words of the full text of this article appear below. |
J P Zhao
Dr J P Zhao, Second Xiangya Hospital, Changsha, China; wurenrong2005@yahoo.com.cn
STUDY DESIGN
randomised placebo controlled trial.
concealed.*
blinded (data collectors, {patients, data analysts, safety committee, and manuscript writers}
).*
STUDY QUESTION
schizophrenia outpatient clinic in China.
128 patients 18–45 years of age (mean age 26 y, 50% men) who were diagnosed with a first psychotic episode of schizophrenia, gained >10% of predrug weight in year 1 of antipsychotic treatment (clozapine, olanzapine, sulpiride, or risperidone), were taking only 1 antipsychotic with 
25% change in dose in the past 3 months, first attended the clinic or were discharged from an inpatient unit <1 year before enrolment, had relatively stable improvement (Positive and Negative Symptom Scale total score 60), and had an adult caregiver who could monitor adherence. Exclusion criteria were liver or renal dysfunction, cardiovascular disease, diabetes mellitus, history of substance abuse, pregnancy or lactation, inability to perform the lifestyle intervention (LSI), and
University of Extremadura Medical School and University Hospital Network, Badajoz, Spain
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Drugs: psychiatry
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Psychotic disorders (incl schizophrenia)
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