PROGNOSIS
Risk of fatal pulmonary embolism was 0.49 per 100 person-years after discontinuing anticoagulant therapy for venous thromboembolism
| The first 150 words of the full text of this article appear below. |
J D Douketis
Dr J D Douketis, St Joseph's Healthcare, Hamilton, Ontario, Canada; jdouket@mcmaster.ca
STUDY QUESTIONS
In patients who have discontinued anticoagulant therapy after a first episode of venous thromboembolism (VTE), what is the risk of fatal pulmonary embolism (PE) and what is the case-fatality rate of recurrent VTE?
STUDY DESIGN
combined analysis of 2 inception cohorts followed for a mean 54 (range 1–120) months.
3 hospitals in Italy (cohort study) and 16 centres in Sweden (randomised trial).
1628 patients from the cohort study and 424 patients from the randomised trial (mean age 62 y, 53% women) who had completed 
3 (mean 6) months of anticoagulant therapy (unfractionated or low-molecular-weight heparin for 5–10 d, followed by a vitamin K antagonist) after a first episode of symptomatic, objectively confirmed VTE. Patients with active cancer, permanent immobility, or high-risk thrombophilia were excluded.
age, sex, duration of initial anticoagulation, study type, initial disease presentation, and cause of
University of California, Davis Sacramento, California, USA
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