THERAPEUTICS
Intensive glucose control increased mortality and did not prevent cardiovascular events in type 2 diabetes
| The first 150 words of the full text of this article appear below. |
R P Byington
Dr R P Byington, Wake Forest University School of Medicine, Winston-Salem, NC, USA; bbyingto@wfubmc.edu
STUDY DESIGN
randomised controlled trial (Action to Control Cardiovascular Risk in Diabetes [ACCORD]).
concealed.*
blinded (outcome adjudication committee and laboratory staff).*
STUDY QUESTION
77 centres in the USA and Canada.
10 251 patients 40–79 years of age (mean age 62 y, 61% men) who had type 2 diabetes, glycated haemoglobin concentration 
7.5%, and cardiovascular disease or, if 55 years of age, risk factors for cardiovascular disease. Exclusion criteria included body mass index >45 kg/m2, serum creatinine concentration >132 mmol/l (1.5 mg/dl), and frequent or recent serious hypoglycaemia.
intensive glucose control to achieve a target glycated haemoglobin concentration <6.0% (n = 5128) or standard glucose control to achieve a target glycated haemoglobin concentration of 7.0–7.9% (n = 5123).
composite of cardiovascular events (non-fatal myocardial infarction or stroke, or death from cardiovascular causes). Secondary outcomes included death from
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