THERAPEUTICS
Lifestyle interventions reduced the long-term risk of diabetes in adults with impaired glucose tolerance
| The first 150 words of the full text of this article appear below. |
G Li
Dr G Li, China-Japan Friendship Hospital, Beijing, China; guangwei_li@medmail.com.cn
STUDY DESIGN
cluster randomised controlled trial (China Da Qing Diabetes Prevention Outcomes Study [CDQDPOS]).
unconcealed.*
blinded (data collectors and outcome adjudicators).*
STUDY QUESTION
33 clinics in Da Qing, China.
577 adults (mean age 46 y, 54% men) with impaired glucose tolerance.
1 of 3 group-based lifestyle interventions for 6 years: diet (to increase vegetable intake, lower alcohol and sugar intake, and reduce weight if indicated), exercise (to increase leisure-time physical activity), or diet plus exercise (n = 438, 3 groups pooled); or usual care (n = 138).
diabetes, cardiovascular disease (CVD) event (myocardial infarction, stroke, sudden death, or amputation), CVD mortality, and all-cause mortality.
94–98% (intention-to-treat analysis).
20 years.
MAIN RESULTS
During the 6-year active intervention period, the pooled lifestyle interventions reduced the risk of diabetes by {38% (95% CI 17 to 55)}
compared with usual care. At 20 years, the risk of diabetes continued
University of Auckland, Auckland, New Zealand
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