THERAPEUTICS
High-concentration capsaicin reduced pain in patients with HIV-associated polyneuropathy
| The first 150 words of the full text of this article appear below. |
D M Simpson
Dr D M Simpson, Mount Sinai Medical Center, New York, NY, USA; david.simpson@mssm.edu
STUDY DESIGN
randomised controlled trial.
unclear concealment.*
blinded {patients and investigators}
.*
STUDY QUESTION
30 centres in the USA.
307 patients (mean age 48 y, 93% men) who had 
2 months of moderate to severe neuropathic pain in both feet (mean Numeric Pain Rating Scale [NPRS] screening score of 3–9) secondary to HIV-associated distal sensory polyneuropathy or neurotoxic antiretroviral treatment. Treatment dose had to be stable for 8 weeks for current antiretroviral drugs and 21 days for other pain medications. Exclusion criteria included use of topical analgesics; pain other than HIV-associated neuropathy; cardiac, renal, hepatic, or pulmonary function abnormalities; hypersensitivity to capsaicin or opioids; and use of 60 mg morphine-equivalent.
225 patients were allocated to a single application of a high-concentration capsaicin dermal patch (640 mcg/cm2, 8% w/w), and 82 were allocated to a low-concentration (control) patch
Vanderbilt University, Nashville, Tennessee, USA
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Pain (neurology)
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Immunology (including allergy)
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HIV/AIDS
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Neuromuscular disease
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