AETIOLOGY
Higher values of fasting plasma glucose within the normal range were associated with increased risk of type 2 diabetes
| The first 150 words of the full text of this article appear below. |
G A Nichols
Dr G A Nichols, Center for Health Research, Portland, OR, USA; greg.nichols@kpchr.org
STUDY QUESTION
Are higher fasting plasma glucose (FPG) concentrations within the normal range associated with increased risk of type 2 diabetes mellitus?
STUDY DESIGN
retrospective cohort study.
health maintenance organisation in Portland, OR, USA.
46 578 people who were >40 years of age (mean age 58 y, 60% women) and had an FPG test result <100 mg/dl (5.6 mmol/l), no previous test result >100 mg/dl, and no diagnosis of diabetes.
FPG, assessed as a continuous variable and in 4 categories. Results were adjusted for potential confounding variables: cardiovascular disease, hypertension, age, sex, body mass index, smoking, blood pressure, and lipids.
type 2 diabetes (ICD-9th Revision–Clinical Modification diagnosis or FPG test result >125 mg/dl [6.9 mmol/l]). Mean length of follow-up was 81 months.
MAIN RESULTS
The figure shows the results. Each mg/dl of FPG increased risk of diabetes by 6% (hazard
Geisinger Medical Center, Danville, Pennsylvania, USA
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