THERAPEUTICS
Benefits of tight blood pressure control to prevent diabetes complications were not sustained
| The first 150 words of the full text of this article appear below. |
R R Holman
Dr R R Holman, Diabetic Trials Unit, Oxford, UK; rury.holman@dtu.ox.ac.uk
STUDY DESIGN
randomised controlled trial (Hypertension in Diabetes Study) within the UK Prospective Diabetes Study (UKPDS). Current Controlled Trials ISRCTN75451837 [controlled-trials.com] .
{concealed}*.
blinded (outcome adjudication committee).
STUDY QUESTION
{20}* centres in the UK.
1148 patients {mean age 56 y, 56% men}* with type 2 diabetes who were already participating in the UKPDS and had hypertension. Exclusion criteria included need for strict BP control or β-blockade and severe illness.
tight BP control with either an angiotensin-converting enzyme (ACE) inhibitor (captopril, 
50 mg twice/d, n = 400) or a β-blocker (atenolol, 100 mg once/d, n = 358), or less-tight BP control without use of an ACE inhibitor or a β-blocker (n = 390). BP targets were <150/85 mm Hg in the tight-control group and <180/105 mm Hg in the less-tight-control group.
7 composite outcomes (any diabetes-related end point, diabetes-related death, death from any
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