THERAPEUTICS
A combination of telmisartan and ramipril increased renal outcomes in vascular disease or diabetes
| The first 150 words of the full text of this article appear below. |
J F Mann
Dr J F Mann, Munich General Hospitals, Ludwig Maximilians University Munchen, Germany; johannes.mann@kms.mhn.de
STUDY DESIGN
randomised controlled trial (Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial [ONTARGET]). ClinicalTrials.gov NCT00153101 [ClinicalTrials.gov] .
concealed.*
blinded (patients, clinicians, and {outcome assessors}
).*
STUDY QUESTION
{733 centres in 40 countries.}
25 620 patients 
55 years of age who had established atherosclerotic vascular disease or diabetes with end-organ damage. At baseline, mean serum creatinine concentration was 94 µmol/l, mean estimated glomerular filtration rate (eGFR) was 74 ml/min/1.73 m2, and mean urine albumin-to-creatinine ratio (UACR) was 0.82 mg/mmol. Exclusion criteria included major renal artery stenosis, uncorrected volume or sodium depletion, serum creatinine concentration >265 µmol/l, and uncontrolled hypertension.
telmisartan, 80 mg/d, plus ramipril, 10 mg/d (n = 8502), telmisartan (n = 8542), or ramipril (n = 8576).
composite end point of dialysis, doubling of serum creatinine concentration, and death; and changes in eGFR concentration
University of Western Ontario London, Ontario, Canada
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