THERAPEUTICS
Review: postmenopausal hormone therapy increases risk of stroke and venous thromboembolism but not coronary heart disease events
| The first 150 words of the full text of this article appear below. |
P M Bath
Dr P M Bath, University of Nottingham, Nottingham, UK; philip.bath@nottingham.ac.uk
QUESTION
What are the effects of hormone therapy (HT) on arterial and venous vascular events in postmenopausal women?
REVIEW SCOPE
Included studies compared risk of vascular events in postmenopausal women receiving HT with that of women receiving placebo or no HT. Outcomes were cerebrovascular disease events (stroke or transient ischaemic attack), coronary heart disease (CHD) events (myocardial infarction, sudden cardiac death, or unstable angina), and venous thromboembolic (VTE) disease events (deep venous thrombosis, pulmonary embolism, or cerebral sinus thrombosis).
REVIEW METHODS
Cochrane Library, Medline, PubMed, and EMBASE/Excerpta Medica (to Jan 2008); and reference lists were searched for randomised controlled trials (RCTs) published in English. 31 trials (n = 44 113, mean age 47–75 y) met the selection criteria. Duration of follow-up ranged from 16 weeks to 7 years (median 2 y).
MAIN RESULTS
HT increased risk of cerebrovascular and VTE events but not
University of Toronto, Toronto, Ontario, Canada
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Menopause (including HRT)
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Drugs: cardiovascular system
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Stroke
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Ischaemic heart disease
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Geriatric medicine
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