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Therapeutics
A single measure of urinary neutrophil gelatinase–associated lipocalin was accurate for diagnosing acute kidney injury

https://doi.org/10.1136/ebm.14.1.20

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    T L Nickolas

    Dr T L Nickolas, Columbia University, New York, NY, USA; tln2001@columbia.edu

    STUDY DESIGN

    Design:

    prospective cohort study.

    Setting:

    an emergency department (ED) in New York, New York, USA.

    Patients:

    635 consecutive patients ⩾18 years of age (mean age 60 y, 51% men) who attended the ED between 06:00 and 24:00. Patients receiving haemodialysis or who did not have >1 serum creatinine measurement were excluded.

    Description of tests:

    urinary neutrophil gelatinase–associated lipocalin (NGAL) was measured using an immunoblotting procedure, serum creatinine using the Jaffe reaction, urinary N-acetyl-β-D-glucosaminidase (NAG) using an enzyme measurement, and α1-microglobulin and α1-acid glycoprotein using immunonephelometery.

    Diagnostic standard:

    clinical diagnosis of acute kidney injury (AKI) was defined as new-onset, 1.5-fold increase in serum …

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    Footnotes

    • Source of funding: Emerald Foundation; National Institutes of Health; March of Dimes; Doris Duke Foundation.