THERAPEUTICS
Review: medication adjustment based on fractional exhaled nitric oxide did not prevent asthma exacerbations
| The first 150 words of the full text of this article appear below. |
H Petsky
Ms H Petsky, Royal Children's Hospital, Brisbane, Queensland, Australia; helen_petsky@health.qld.gov.au
QUESTION
In adults and children with asthma, does medication adjustment based on fractional exhaled nitric oxide (FeNO) concentration prevent asthma exacerbations more than adjustment based on clinical symptoms?
REVIEW SCOPE
Included studies compared adjustment of asthma medication based on FeNO concentrations with adjustment based on clinical symptoms (with or without spirometry) in adults or children with "classical" asthma. Outcomes were asthma exacerbations, symptom scores, and final and cumulative dose of inhaled corticosteroids.
REVIEW METHODS
Cochrane Airways Group Specialised Register of Trials, Cochrane Central Register of Controlled Trials (Issue 4, 2006), Medline and EMBASE/Excerpta Medica (to Dec 2006), Old Medline (1950–65), and references were searched for randomised controlled trials (RCTs). Authors of included trials were consulted. 4 RCTs (n = 356) met the selection criteria: 2 RCTs in children (n = 141, mean age 12 y, 63% boys), 1 RCT in adults (n =
Queen Elizabeth Hospital Woodville, South Australia, Australia
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Immunology (including allergy)
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Asthma
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Drugs: CNS (not psychiatric)
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Drugs: respiratory system
- Clinical trials (epidemiology)
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