THERAPEUTICS
Tiotropium reduced exacerbations but not rate of FEV1 decline in patients with COPD using other respiratory medications
| The first 150 words of the full text of this article appear below. |
D P Tashkin
Dr D P Tashkin, University of California, Los Angeles, Los Angeles, CA, USA; dtashkin@mednet.ucla.edu
STUDY DESIGN
randomised placebo-controlled trial (Understanding Potential Long-Term Impacts on Function with Tiotropium [UPLIFT]). ClinicalTrials.gov NCT00144339 [ClinicalTrials.gov] .
concealed.*
blinded (clinicians, patients, data collectors, and outcome adjudication committee).*
STUDY QUESTION
490 centres in 37 countries worldwide.
5993 patients 
40 years of age (mean age 65 y, 75% men) who had COPD, a history of 10 pack-years of smoking, and postbronchodilation FEV1 
70% of predicted and 70% of FVC. Exclusion criteria included a history of asthma or pulmonary resection, recent COPD exacerbation or respiratory infection, and use of supplemental oxygen for 12 hours/day.
inhaled tiotropium, 18 µg once daily (n = 2987), or placebo (n = 3006). Additional use of any respiratory medication, except other inhaled anticholinergic drugs, was allowed.
primary outcomes were rate of decline in mean FEV1 before and after use of the study drug and a
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