THERAPEUTICS
Ondansetron reduced the need for intravenous hydration in children with acute gastritis/gastroenteritis and dehydration
| The first 150 words of the full text of this article appear below. |
G Roslund
Dr G Roslund, St Joseph Regional Medical Center, South Bend, IN, USA; groslund@hotmail.com
STUDY DESIGN
randomised, placebo-controlled trial.
concealed.*
blinded (patients, parents, healthcare providers, outcome assessors, and data collectors).*
STUDY QUESTION
emergency department (ED) of a hospital in Chicago, USA.
106 children 1–10 years of age (mean age 4 y, 56% girls) who had a clinical diagnosis of acute gastritis/gastroenteritis (AGE) with mild or moderate dehydration and failed oral rehydration in the ED. Children who had received an antiemetic agent in <6 hours, had a chronic illness, or were in shock were excluded.
2, 4, or 6 mg ondansetron as orally dissolving tablets (for children weighing <15, 15–30, or >30 kg, respectively) (n = 51) or placebo (n = 55). Oral rehydration was reattempted 30 minutes later. Children who tolerated the oral challenge were discharged after drinking 40 ml/kg over 2 hours. Children who failed the oral challenge (vomited or refused liquids)
University of Western Ontario London, Ontario, Canada
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