THERAPEUTICS
Telmisartan did not prevent recurrent stroke or major cardiovascular events
| The first 150 words of the full text of this article appear below. |
S Yusuf
Dr S Yusuf, McMaster University, Hamilton, Ontario, Canada; yusufs@mcmaster.ca
STUDY DESIGN
randomised placebo-controlled trial with 2 x 2 factorial design (Prevention Regimen for Effectively Avoiding Second Strokes [PRoFESS]). ClinicalTrials.gov NCT00153062 [ClinicalTrials.gov] .
concealed.*
blinded {patients, clinicians, data collectors, outcome assessors, safety committee, and data analysts}
.*
STUDY QUESTION
695 centres in 35 countries worldwide.
20 332 patients 
50 years of age (mean age 66 y, 64% men) who had had an ischaemic stroke in the previous 120 days and were clinically and neurologically stable.
telmisartan, 80 mg/d (n = 10 146), or placebo (n = 10 186). Patients were also randomised to 1 of 2 antiplatelet regimens (see Sacco abstract).
recurrent stroke of any type, a composite end point of major cardiovascular events (stroke, myocardial infarction, worsening or new heart failure, or death from cardiovascular causes), and new-onset diabetes. The trial had 91% power to detect a relative risk reduction of 15% in
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