THERAPEUTICS
Rosuvastatin prevented major cardiovascular events in people with elevated C-reactive protein
| The first 150 words of the full text of this article appear below. |
P M Ridker
Dr P M Ridker, Brigham and Women’s Hospital, Boston, MA, USA; pridker@partners.org
STUDY DESIGN
randomised placebo-controlled trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin [JUPITER]). ClinicalTrials.gov NCT00239681 [ClinicalTrials.gov] .
concealed.*
blinded (patients, clinicians, data collectors, and outcome adjudication committee).*
STUDY QUESTION
1315 sites in 26 countries.
17 802 men 
50 years of age or women 60 years of age (mean age 66 y, 62% men) who had no history of cardiovascular (CV) disease, high-sensitivity C-reactive protein concentrations 2.0 mg/l, low-density lipoprotein cholesterol levels <3.4 mmol/l (130 mg/dl), and triglyceride concentrations <5.6 mmol/l (500 mg/dl). Exclusion criteria included previous use of a lipid-lowering drug; uncontrolled hypertension or hypothyroidism; and diabetes.
rosuvastatin, 20 mg daily (n = 8901), or placebo (n = 8901) for 
5 years.
composite of CV events (non-fatal myocardial infarction or stroke, hospital admission for unstable angina, arterial revascularisation procedure, or confirmed CV death), components
University of Michigan, Flint, Michigan, USA
Mayo Clinic, Rochester, Minnesota, USA
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