THERAPEUTICS
Specific oral tolerance induction increased tolerance to milk in children with severe cow’s milk allergy
| The first 150 words of the full text of this article appear below. |
E Barbi
Dr E Barbi, University of Trieste, Trieste, Italy; ebarbi@libero.it
STUDY DESIGN
randomised controlled trial.
concealed.*
unblinded.*
STUDY QUESTION
children’s hospital in Trieste, Italy.
60 children 5–17 years of age (mean age 8 y, 65% boys) who had a history of severe allergic reaction after exposure to milk or dairy products, milk-specific serum IgE concentrations >85 kUA/l, and a positive reaction to a double-blind, placebo-controlled food challenge of 
0.8 ml of whole milk. Exclusion criteria were unreliable management of complications by parents, limited access to emergency care, and poorly controlled asthma.
specific oral tolerance induction (SOTI) (n = 30) or maintenance of a milk-free diet (n = 30). The SOTI protocol consisted of 10 days in hospital during which children were given rapidly increasing doses of milk, up to 20 ml whole milk/dose. At home, children continued with slowly increasing doses as tolerated. Parents were instructed about managing adverse reactions. Children received daily
Montreal Children's Hospital, Montreal, Quebec, Canada
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Immunology (including allergy)
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Diet
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Childhood nutrition
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Interventional cardiology
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Drugs: CNS (not psychiatric)
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