THERAPEUTICS
Laparoscopic surgery was more effective than medical management for GORD disease
| The first 150 words of the full text of this article appear below. |
A Grant
Dr A Grant, University of Aberdeen, Aberdeen, UK; a.grant@abdn.ac.uk
STUDY DESIGN
randomised controlled trial and economic analysis. Current Controlled Trials ISRCTN15517081 [controlled-trials.com] .
concealed.*
unblinded.*
STUDY QUESTION
21 hospitals in the UK.
357 patients 
18 years of age (mean age 46 y, 66% men) who had documented evidence of gastro-oesophageal reflux disease (GORD) and symptoms for >12 months and for whom the best management policy was uncertain. Exclusion criteria included body mass index >40 kg/m2, Barrett oesophagus >3 cm, evidence of dysplasia, paraoesophageal hernia, and oesophageal stricture.
a strategy of laparoscopic fundoplication (technique selected by surgeon) (n = 178) or a strategy of best medical management with proton pump inhibitors (PPIs) or histamine-receptor antagonists (n = 179).
primary outcome was REFLUX quality-of-life score. Secondary outcomes included 5 REFLUX symptoms scores, quality-adjusted life-years (QALYs, based on EuroQol-5 Dimensions instrument), and healthcare costs.
12 months after surgery or an equivalent time in patients who
Sigma Surgery, Baroda, Gujarata, India
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