DIAGNOSIS
Review: C-reactive protein has moderate diagnostic accuracy for serious bacterial infection in children with fever
| The first 150 words of the full text of this article appear below. |
S Sanders
Ms S Sanders, University of Queensland, Brisbane, Queensland, Australia; s.sanders@uq.edu.au
QUESTION
What is the diagnostic accuracy of C-reactive protein (CRP) for bacterial infections in children with fever?
REVIEW SCOPE
Included studies compared blood or serum CRP with a reference standard for microbiological diagnosis of bacterial v non-bacterial infection or serious bacterial v benign bacterial or non-bacterial infection in children initially presenting with fever. Excluded were studies involving >10% neonates, children admitted to hospital outside of the emergency department (ED) or with a specific medical condition (eg, cancer or renal failure), or in which the reference standard was diagnosis of a specific disease (eg, meningitis, gastroenteritis, or arthritis). Outcome measures were sensitivity, specificity, positive and negative likelihood ratios, and diagnostic odds ratio.
REVIEW METHODS
Medline and EMBASE/Excerpta Medica (both to Dec 2007), and reference lists were searched for studies. Authors were contacted for additional information. 10 studies evaluating CRP met the selection criteria: 7
Alfred I duPont Hospital for Children, Wilmington, Delaware, USA
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Meningitis
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Infection (neurology)
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