Register for email alerts and news feeds:
This journal | BMJ Group
rss
Evidence-Based Medicine 2009;14:70; doi:10.1136/ebm.14.3.70
Copyright © 2009 by the BMJ Publishing Group Ltd.

Letter: Viewing JUPITOR with a clear perspective

Cyrus R Kumana, Hung Fat Tse, C P Lau

University of Hong Kong, Hong Kong, China

The first 150 words of the full text of this article appear below.

The findings of the JUPITOR study1 that was terminated prematurely after a median follow-up of 1.9 years are impressive but should be viewed in the perspective of results from other major clinical trials with statins. As previously described,2 we calculated corresponding crude event rates (table) from this and other published clinical trials with statins. JUPITOR reported the effects of rosuvastatin, 20 mg/day, in a trial of 17 802 participants with C-reactive protein concentrations >= 2mg/l and a median age of 66 years. For the primary end point (a composite of 5 events occurring for the first time), the relative risk (RR) was 57% and the number needed to treat (NNT)/year was 155. For fatal and non-fatal myocardial infarction (MI), the RR was 46% and the NNT/year was 457.

The latter end point was the closest to that of the 4S trial3 shown in the table, in which simvastatin-treated patients with both . . . [Full text of this article]


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

This Article

Services
Google Scholar
PubMed
Bookmark with

Register for free content

The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.