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Evidence-Based Medicine 2009;14:73; doi:10.1136/ebm.14.3.73
Copyright © 2009 by the BMJ Publishing Group Ltd.

THERAPEUTICS

Intensive and standard glucose control did not differ for CV events or death in poorly controlled type 2 diabetes

The first 150 words of the full text of this article appear below.


STUDY DESIGN

Design:

randomised controlled trial (Veterans Affairs Diabetes Trial [VADT]). ClinicalTrials.gov NCT00032487 [ClinicalTrials.gov] .

Allocation:

unclear allocation concealment.*

Blinding:

blinded (outcome assessors).*


STUDY QUESTION

Setting:

20 sites in the USA.

Patients:

1791 patients (mean age 60 y, 97% men) who had inadequate responses to maximum doses of an oral agent or insulin therapy. Exclusion criteria included glycated haemoglobin (HbA1c) concentration <7.5%, cardiovascular (CV) event in the past 6 months, advanced congestive heart failure (CHF), severe angina, body mass index (BMI) >40 kg/m2, serum creatinine concentration >1.6 mg/dl (141 µmol/l), and alanine aminotransferase concentration >3 times the upper normal limit.

Intervention:

intensive (n = 892) or standard glucose control (n = 899). Patients were given oral metformin plus rosiglitazone (BMI >=27 kg/m2) or oral glimepiride plus rosiglitazone (BMI <27 kg/m2). The intensive-control group started with maximum doses, and the standard-control group started with half-maximum doses. Patients in the intensive-control group who did not achieve HbA1c concentrations <6% . . . [Full text of this article]

Gillian L Booth

St Michael's Hospital, University of Toronto Toronto, Ontario, Canada


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