PROGNOSIS
Review: long-term annual conversion rate to dementia was 3.3% in elderly people with mild cognitive impairment
| The first 150 words of the full text of this article appear below. |
QUESTION
In elderly people with mild cognitive impairment (MCI), what is the long-term rate of conversion to dementia?
REVIEW SCOPE
Included studies examined the progression of MCI, defined according to accepted criteria. Outcomes were dementia or probable Alzheimer disease.
REVIEW METHODS
Medline, EMBASE/Excerpta Medica, and PsycINFO (to Mar 2008) were searched for cohort studies with 
5 years of follow-up. 15 studies (n = 2404, mean age 62–82 y) met the selection criteria. Mean follow-up was 6 years (range 5–10 y).
MAIN RESULTS
The cumulative conversion rate to dementia was 31% (15 studies) and to Alzheimer disease was 33% (11 studies). The table shows annual conversion rates. Annual conversion rates were lower in studies with longer duration of follow-up.
CONCLUSION
In elderly people with mild cognitive impairment who were followed for 
10 years, the annual conversion rate to dementia was 3.3%.
Abstract and commentary also appear in ACP Journal Club. A modified version of the abstract appears in
St Vincent's Hospital Sydney, New South Wales, Australia
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Memory disorders (psychiatry)
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Memory disorders (neurology)
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Psychiatry of old age
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Geriatric medicine
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