THERAPEUTICS
Intensive primary care treatment reduced cardiovascular risk factors in screen-detected type 2 diabetes
| The first 150 words of the full text of this article appear below. |
STUDY DESIGN
cluster-randomised controlled trial (Dutch part of the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care [ADDITION]). ClinicalTrials.gov NCT00237549 [ClinicalTrials.gov] .
{concealed}*.
blinded (patients and data collectors).
STUDY QUESTION
79 general practices in the Netherlands.
498 patients 50–70 years of age (mean age 60 y, 54% men) who were newly diagnosed with type 2 diabetes by a 2-stage screening process. Patients with psychiatric or cognitive disorders, current treatment for cancer, or a poor prognosis were excluded.
intensive treatment, including special physician training and frequent follow-up by a diabetes nurse, to lower glucose concentrations (target haemoglobin [Hb] A1c concentration 
7.0%), blood pressure (BP, target 120/80 mm Hg), and lipid concentrations (target total cholesterol concentration <3.5 mmol/l) combined with structured lifestyle education (37 practices, 255 patients); or routine care according to national guidelines (42 practices, 243 patients).
changes in body mass index, BP, HbA1c concentration, and serum lipid concentrations; and health-related
University of Auckland, Auckland, New Zealand
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General practice / family medicine
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Screening (public health)
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