THERAPEUTICS
1 day of nitrofurantoin was not as effective as 7 days for asymptomatic bacteriuria in pregnancy
| The first 150 words of the full text of this article appear below. |
STUDY DESIGN
randomised controlled trial.
concealed.*
blinded (patients, healthcare providers, data collectors, and outcome assessors).*
STUDY QUESTION
antenatal clinics in 7 hospitals in Thailand, the Philippines, Vietnam, and Argentina.
778 pregnant women (mean age 27 y) at 12–32 weeks of gestation who were diagnosed (by a 2-step screening process) as having asymptomatic bacteriuria caused by a micro-organism sensitive to nitrofurantoin. Women with symptoms of urinary tract infection (UTI), treatment of UTI in the current pregnancy, a condition requiring continuous steroid or antibiotic therapy, antibiotic hypersensitivity, or haematological disease (including glucose-6-phosphate dehydrogenase deficiency) were excluded.
nitrofurantoin, 100 mg orally twice daily, for 1 day (n = 386) or 7 days (n = 392). The 1-day group received placebo tablets after day 1 to maintain blinding.
bacteriological cure, symptomatic UTI, gestational age at delivery, birth weight, congenital malformations, and adverse effects.
14 days (bacteriological cure) and to delivery.
90–95% (intention-to-treat analysis).
MAIN RESULTS
Bacteriological cure rate was lower
Kings College London London, UK
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Topic Collections
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Pregnancy
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Urinary tract infections
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Vulvovaginal disorders
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Urinary tract infections
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Screening (epidemiology)
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