THERAPEUTICS
Continued use of antipsychotic drugs increased long-term mortality in patients with Alzheimer disease
| The first 150 words of the full text of this article appear below. |
STUDY DESIGN
randomised placebo-controlled trial (DART-AD). ISRCTN33368770 [controlled-trials.com] .
concealed.*
blinded {patients, caregivers and relatives, clinicians, people administering trial drugs, and outcome assessors}
.*
STUDY QUESTION
nursing or residential care facilities in the UK.
165 patients (mean age 85 y, 76% women) who lived in nursing or residential homes, had possible or probable Alzheimer disease (AD, National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer’s Disease and Related Disorders Association criteria) and a Mini-Mental State Examination score >6 or Severe Impairment Battery score >30, and were taking antipsychotic drugs (APDs) for 
3 months for behavioural or psychiatric disturbance (risperidone, 0.5 mg/d or 10 mg of chlorpromazine or equivalent of thioridazine, haloperidol, or trifluoperazine). Exclusion criteria were inability to take capsules or complete baseline assessment for primary outcomes, prolonged QT interval corrected for heart rate on electrocardiogram in patients using thioridazine, and any physical condition that would make participation distressing.
83 patients were allocated to continued
UC Davis Medical Center Sacramento, California, USA
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Drugs: psychiatry
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