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Evidence-Based Medicine 2009;14:121; doi:10.1136/ebm.14.4.121
Copyright © 2009 by the BMJ Publishing Group Ltd.

THERAPEUTICS

Review: adding dexamethasone to standard therapy reduces short-term relapse for acute migraine in the emergency department

The first 150 words of the full text of this article appear below.


QUESTION

Does dexamethasone prevent relapse in patients presenting to the emergency department (ED) with acute migraine headache?


REVIEW SCOPE

Included studies evaluated adjuvant dexamethasone for acute migraine headache diagnosed and treated in the ED and reported the proportion of patients with self-reported moderate or severe headache at 24–72 hours as an outcome. Moderate or severe headache was defined as severe headache that interferes with daily activities or requires a physician visit (last 2 categories on a 5-point scale), moderate or severe headache (last 2 categories on a 4-point scale), or presence of headache on a dichotomous scale. Other outcomes included adverse events.


REVIEW METHODS

Randomised controlled trials (RCTs) in which patients and treating physicians were blinded were retrieved from Medline (1950–May 2008); EMBASE/Excerpta Medica, CINAHL, LILACS, and Cochrane Central Register of Controlled Trials {all to May 2008}*; ClinicalTrials.gov; reference lists; and abstracts from major emergency medicine conferences published in the past 7 years. Authors were . . . [Full text of this article]

Christopher R Carpenter

Parenteral Washington University in St. Louis, St Louis, Missouri, USA


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