OTHER
Therapeutics
Screening for CAD in asymptomatic patients with type 2 diabetes did not reduce risk of cardiac events
| The first 150 words of the full text of this article appear below. |
randomised controlled trial (Detection of Ischemia in Asymptomatic Diabetics [DIAD]). ClinicalTrials.gov NCT00769275 [ClinicalTrials.gov] .
concealed.*
blinded (outcome adjudication committee).*
14 centres in the USA and Canada.
1123 patients 50–75 years of age (mean age 61 y, 54% men) who had type 2 diabetes diagnosed at 
30 years of age, no symptomatic or previously recognised coronary artery disease (CAD), and no history of ketoacidosis.
screening with adenosine-stress radionuclide myocardial perfusion imaging (MPI; n = 561) or no screening (n = 562). Screening results were provided to patients and their physicians; further diagnostic testing and treatment were done at their discretion.
primary outcome was a composite of non-fatal myocardial infarction and cardiac death. Secondary outcomes included unstable angina, heart failure, stroke, and coronary revascularisation. The trial had >80% power to detect a 20% relative difference in cardiac event rate with 
= 0.05, based on an event rate of 5–10%.
median 5 years.
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Drugs: cardiovascular system
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Ischaemic heart disease
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Screening (epidemiology)
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Screening (public health)
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Clinical diagnostic tests
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