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Therapeutics
Review: bariatric surgery reduces weight and improves type 2 diabetes in adults
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Does bariatric surgery reduce weight and improve type 2 diabetes in adults?
Included studies evaluated any kind of bariatric surgery (gastric banding, gastroplasty, gastric bypass, and biliopancreatic diversion/duodenal switch) and reported weight loss and type 2 diabetes status. Outcomes included absolute weight, percentage of excess body weight (ie, amount above normal body weight) lost, and resolution (ie, being off medication and fasting plasma glucose [FPG] concentration <100 mg/dl) or improvement (reduced medication or FPG concentration 100–125 mg/dl) of diabetes.
Medline, Current Contents, Cochrane Library, and reference lists were searched for interventional or observational studies. 621 studies (n = 135 246, age range 16–65 y, mean age 40 y, 80% women) met the selection criteria: 29 (n = 3360) were randomised controlled trials (RCTs) with Jadad scores of 1–3 for 27 RCTs and 4–5 for 2 RCTs.
Meta-analysis showed that bariatric surgery led to weight loss and resolution or
University of Alberta, Edmonton, Alberta, Canada
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