OTHER
Therapeutics
Review: nicotine replacement therapy as assisted "reduction-to-stop" reduces smoking and sustains abstinence in smokers
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Is nicotine replacement therapy (NRT) effective and safe when used to reduce smoking with the aim of stopping (assisted reduction-to-stop)?
Included studies compared NRT using gum or inhaler with placebo, no treatment, non-NRT drugs, or psychological interventions and reported smoking abstinence in smokers who were unwilling or unable to stop smoking abruptly. Adjunct therapies, where used, had to be included in both treatment groups. Primary outcome was sustained smoking abstinence for 6 months. Other outcomes were sustained smoking reduction or abstinence from 6 weeks to study end and adverse events (AEs).
Medline, CINAHL, EMBASE/Excerpta Medica, PsycINFO, Cochrane Library, and Science Citation Index (all 1992–Nov 2007); registries of ongoing trials; and reference lists were searched for published or unpublished randomised controlled trials (RCTs). Experts and drug companies sponsoring NRT trials were contacted. 7 RCTs (n = 2767 in analysis, mean age range 42–46 y, 52% women, treatment duration 6–18
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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