OTHER
Therapeutics
Blood pressure–lowering did not improve short-term mortality or dependency in acute stroke and hypertension
| The first 150 words of the full text of this article appear below. |
randomised placebo controlled trial (Controlling Hypertension and Hypotension Immediately Post Stroke [CHHIPS] study).
concealed.*
blinded (patients and researchers).*
6 centres in England, UK.
179 patients >18 years of age with a fixed neurological deficit lasting >60 min, clinical diagnosis of suspected stroke, and symptom onset within 36 hours (depressor group) and hypertension (mean systolic blood pressure [BP] level >160 mm Hg). Exclusion criteria included current antihypertensive therapy in non-dysphagic patients, contraindications to trial therapy, and significant comorbidity or life expectancy <6 months. The pressor group (symptom onset <12 h and hypotension) had only 1 patient, was discontinued, and is not reported here.
lisinopril, 5–15 mg daily (n = 58), labetalol, 50–150 mg on day 1 then 100–300 mg daily (n = 58), or placebo (n = 63) for 2 weeks, with the dose dependent on achieving target systolic BP. Treatment was given orally in non-dysphagic patients and sublingually (lisinopril)
Northwestern University Feinberg School of Medicine, Chicago, Illinois, US
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