OTHER
Therapeutics
Review: oral vitamin D prevents non-vertebral and hip fractures in a dose-dependent manner in patients 
65 years of age
| The first 150 words of the full text of this article appear below. |
In patients 
65 years of age, does oral vitamin D prevent non-vertebral and hip fractures?
Included studies evaluated oral vitamin D supplementation and reported 1 fracture in patients with mean age 65 years; studies had to be double-blind and have 1 year of follow-up. Exclusion criteria included uncontrolled, observational, or animal studies; and studies of patients with organ transplantation or stroke, and those taking steroids or treatment for Parkinson disease. Outcomes were first or repeated non-vertebral fracture or hip fracture.
Medline and Cochrane Controlled Trials Register (1960 to Aug 2008), EMBASE/Excerpta Medica (1991 to Aug 2008), reference lists, and abstracts from the American Society of Bone and Mineral Research (1995–2007) were searched, and experts were contacted for randomised controlled trials (RCTs). 12 high-quality RCTs (n = 42 279, mean age 78 y, 89% women) met the selection criteria.
Meta-analysis showed that vitamin D doses >400 IU/d (range 482 to
Northwick Park Hospital, Harrow, UK
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Clinical trials (epidemiology)
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Injury
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Geriatric medicine
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Immunology (including allergy)
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Drugs: CNS (not psychiatric)
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