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Evidence-Based Medicine 2009;14:151; doi:10.1136/ebm.14.5.151
Copyright © 2009 by the BMJ Publishing Group Ltd.

OTHER

Aetiology

Higher red blood cell distribution width was associated with increased risk of mortality in adults >=45 years of age

The first 150 words of the full text of this article appear below.

Study question

Is a higher red blood cell distribution width (RDW) associated with increased risk of mortality in adults >=45 years of age?

Study design

Design:

cohort study.

Setting:

USA.

Participants:

8175 participants >=45 years of age (mean age 62 y, 54% women) from the civilian non-institutionalised population. 3 participants were excluded because insufficient information was available to search the National Death Index.

Risk factors:

RDW values were divided by quintiles (12.6–12.95%, 13–13.4%, 13.45–14.05%, and >14.05%). Results were adjusted for age, sex, and ethnicity.

Outcomes:

all-cause mortality.

Main results

Overall, 2428 (30%) participants died during 12 years of follow-up. Increasing RDW values were associated with increasing risk of all-cause mortality (table). Every 1% increase in RDW was associated with 22% increased risk of mortality after adjusting for multiple risk factors.

Conclusion

Higher red blood cell distribution width was associated with increased risk of mortality in adults >=45 years of age.

Abstracted from

Patel KV, Ferrucci L, Ershler WB, et al. Red blood . . . [Full text of this article]

Robert T Means Jr

University of Kentucky, Lexington, Kentucky, USA


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