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Aetiology
BMI <22.5 and >25 predicted higher overall mortality in adults
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What is the association between body mass index (BMI) and mortality in adults?
Included studies provided data on BMI and death. Analyses excluded people with BMI <15 kg/m2 or 
50 kg/m2 or history of heart disease or stroke. Outcomes were overall mortality and cause-specific mortality (>50 specific causes of death).
{Medline, EMBASE/Excerpta Medica, and conference abstracts were searched and investigators were contacted}* for prospective studies. 57 studies (n = 894 576, mean age 46 y, 61% men) met the selection criteria.
BMI ranging from 22.5 to 25 kg/m2 was associated with lowest overall mortality. In people with BMIs of 25–50 kg/m2, each 5 kg/m2 higher BMI was associated with 30% higher overall mortality; 40% for vascular mortality; 60–120% for diabetic, renal, and hepatic mortality; 10% for neoplastic mortality; and 20% for respiratory and other mortality. The table shows the results.
Body mass index <22.5 kg/m2 and >25 kg/m2
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
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