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HIV transmission risk during breast feeding was greatest during the early months of life

Design
Cohort study with 24 month follow up.

Setting
A tertiary care hospital in Blantyre, Malawi.

Participants
672 infants who were born to HIV infected women who had not received antiretroviral drugs during pregnancy or after childbirth. Infants had to be HIV negative on the first postnatal visit at 6 weeks of age, be breast fed, and have a second follow up visit.

Assessment of risk factors
Time of infant HIV infection through breast feeding was taken to be the midpoint between the last postnatal negative polymerase chain reaction (PCR) test result and the first postnatal positive PCR test result. Time at risk for infant HIV infection through breast feeding was the interval between the first postnatal negative PCR test result and the first postnatal positive PCR test result. Potential risk factors assessed included mother's age, maternal symptoms of HIV or death within 2 years of giving birth, parity, delivery mode, breast problems (painful swelling, other signs . . . [Full text of this article]

Clay Triplehorn, DO¹, Kimberly A Moody, PhD, RN-CS, ANP²

¹ Family Practice Residency Program Bangor, Maine, USA
² University of Southern Maine Portland, Maine, USA