© 2000 Evidence-Based Medicine
Review: antidepressive agents improve symptoms and reduce pain in patients with functional gastrointestinal disorders
Jackson JL, O'Malley PG, Tomkins G, et al.Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis.Am J Med 2000 Jan;108:65–72[Medline]
QUESTION: Are antidepressive agents efficacious for treating patients with functional gastrointestinal (GI) disorders?
Studies were identified by searching Medline (1966–98), PsycLIT (1974–98), EMBASE/Excerpta Medica (1974–98), the Cochrane Library, and the Federal Research in Progress database using the terms antidepressive agents, serotonin reuptake inhibitors, monoamine oxidase inhibitors, amoxapine, clomipramine, tramipramine, desipramine, doxepin, imipramine, amitriptyline, maprotiline, nortriptyline, protriptyline, trazodone, nefazodone, fluoxetine, fluvoxamine, paroxetine, sertraline, femosetine, venlafaxine, bupropion, citalopram, mianserin, pizotyline, pizotifen, functional colonic diseases, dyspepsia, and abdominal pain. Bibliographies of relevant reviews and studies were scanned.
Randomised controlled trials were selected if they compared an antidepressive agent with placebo in an adult population and outcome data were provided.
Data were extracted on study quality, setting, country, dose, study duration, follow up, patient numbers and characteristics, comorbid psychiatric disease, adverse effects, outcomes (pain or symptom improvement), and quality indicators.
90 citations were reviewed, and 11 met the inclusion criteria. Quality scores were moderate with a mean score of 4 on a 9 point scale. 9
Hammersmith Hospital London, UK
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