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Evidence-Based Medicine 2000; 5:120
© 2000 Evidence-Based Medicine

Local injection, naproxen, and simple analgesia led to similar 1 year rates of symptom relief in lateral epicondylitis

Hay EM, Paterson SM, Lewis M, et al.Pragmatic randomised controlled trial of local corticosteroid injection and naproxen for treatment of lateral epicondylitis of elbow in primary care.BMJ 1999 Oct 9;319:964–8[Abstract/Free Full Text]

QUESTION: In adults with lateral epicondylitis (tennis elbow), which of 3 regimens (local corticosteroid injection, 2 weeks of naproxen, or simple analgesia) is most effective?

Design
Randomised {allocation concealed*}{dagger}, blinded (outcome assessor and statistician),* placebo controlled trial with 12 months follow up.

Setting
23 primary care practices in North Staffordshire and South Cheshire, England.

Patients
164 patients who were 18–70 years of age (66% >=45 y, 52% men) and had consulted their general practitioner because they had had a new episode of lateral epicondylitis. Exclusion criteria were a history of inflam-matory arthritis or gross structural abnormality of the elbow, contraindications to non-steroidal anti-inflammatory drugs (NSAIDs) or local steroid injection, pregnancy, or breast feeding. 98% of patients were included in the analysis for 4 week complete recovery, 96% for 4 week and 12 month pain severity, and 98% for 6 month pain severity.

Intervention
Patients were allocated to a local corticosteroid injection of methylprednisolone, 20 mg, and 1% lignocaine, 0.5 ml (n=53); enteric coated naproxen, 500 mg twice daily for 2 weeks (n=53); or placebo for 2 weeks . . . [Full text of this article]

Anthony S Dixon, MBChB

University of Hong Kong Hong Kong, China







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