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Evidence-Based Medicine 2001; 6:186
© 2001 Evidence-Based Medicine

Review: oral melatonin reduces jet lag in air travellers

Herxheimer A, Petrie KJ. Melatonin for preventing and treating jet lag. Cochrane Database Syst Rev 2001;(1):CD001520 (latest version 22 Aug 2000).

QUESTION: In people who travel by air across several time zones, can oral melatonin prevent or treat jet lag (daytime fatigue, sleep disturbances, loss of mental efficiency, weakness, and irritability)?

Data sources
Studies were identified by searching the Cochrane Controlled Trials Register, Medline, EMBASE/Excerpta Medica, and PsycLIT with the terms melatonin, jet-lag, jet lag, aviation, air travel, and airtravel. Specific studies were identified in SciSearch, 2 journals (Aviation, Space and Environmental Medicine and Sleep from 1986 to 1999) were hand searched, bibliographies of relevant studies were scanned, and authors of studies were contacted to identify further studies. Data and case reports of adverse effects of melatonin were also sought.

Study selection
Randomised controlled trials were selected if airline passengers, airline staff, or military personnel were studied; oral melatonin was compared with placebo or other medication; drugs were taken before, during, or after travel or a combination of times related to travel; and outcome data were provided.

Data extraction
Data were extracted on study quality and participants, timing and dose of melatonin and other study medications, flight information, and outcomes of subjective ratings of jet lag . . . [Full text of this article]

Colin M Shapiro, MD, PhD

Toronto Western Research Institute Toronto, Ontario, Canada






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