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Progression of disease in HIV infected children slowed after the first year of life

Design
Cohort study with a median 5.8 years of follow up.

Setting
11 paediatric centres in 7 European countries.

Patients
170 HIV infected children who were born to mothers known to be infected with HIV at the time of delivery.

Assessment of prognostic factors
Children were categorised into 3 cohorts according to the treatment policy at the time of their birth. Cohort 1 consisted of children born during 1985 to 1988 when no recommendations for treatment existed; cohort 2 consisted of children born during 1989 to 1994 when the treatment policy was restricted to monotherapy for symptomatic children; and cohort 3 consisted of children born during 1995 to 1999 when the initiation of combination treatments was recommended at an early stage. Children were allocated to Centers for Disease Control and Prevention (CDC) categories for clinical manifestations (N = asymptomatic; A = mildly symptomatic; B = moderately severe symptoms, including lymphoid interstitial pneumonitis; C = severe symptoms; and . . . [Full text of this article]

Susan King, MD

Hospital for Sick Children Toronto, Ontario, Canada