HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Montori, V. M Search for Related Content PubMed Articles by Montori, V. M

A lifestyle intervention or metformin prevented or delayed the onset of type 2 diabetes in people at risk

Key Words: diabetes mellitus • non-insulin dependent • lifestyle • metformin

The first 150 words of the full text of this article appear below.

Design
Randomised (allocation concealed^*), blinded (clinicians and participants for metformin and placebo),^* placebo controlled trial with mean follow up of 2.8 years.

Setting
27 centres in the US.

Participants
3234 participants (mean age 51 y, 68% women) without diabetes who had a body mass index 24 (22 for Asians) and a plasma glucose concentration of 5.3 to 6.9 mmol/l in the fasting state and 7.8 to 11.0 mmol/l 2 hours after a 75 g oral glucose load. Exclusion criteria included medications known to alter glucose tolerance and illnesses that could seriously reduce life expectancy or ability to participate in the trial. Follow up was 93%.

Intervention
Participants were allocated to an intensive programme of lifestyle modification (n=1079), standard lifestyle recommendations plus glucose control with metformin (850 mg twice daily) (n=1073), or placebo (n=1082). The intensive lifestyle intervention consisted of a 16 lesson curriculum aimed at achieving and maintaining a weight reduction of . . . [Full text of this article]

Victor M Montori, MD, MSc

Mayo Clinic
Rochester, Minnesota, USA