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Increased plasma total homocysteine levels increased the risk for dementia in the elderly

Key Words: dementia • homocysteine

The first 150 words of the full text of this article appear below.

Design
Cohort study with a median follow up of 8 years.

Setting
Framingham, Massachusetts, USA.

Participants
1092 elderly participants (mean age 76 y, 61% women) from the Framingham Study cohort who were free from dementia and had plasma total homocysteine levels measured at their 20th biennial examination.

Assessment of risk factors
Baseline data were collected on the plasma total homocysteine level. Analyses were adjusted for baseline age; sex; apolipoprotein E genotype (93% of participants); plasma levels of folate (98% of participants), vitamin B-12 (85% of participants), and vitamin B-6 (92% of participants); educational status; history of stroke; cigarette smoking; alcohol intake; diabetes mellitus; systolic blood pressure; and body mass index.

Main outcome measures
Dementia (Diagnostic and Statistical Manual of Mental Disorders, 4th edition, criteria; symptoms > 6 months in duration; and Clinical Dementia Rating scale severity of dementia score 1) and Alzheimer’s disease (National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related . . . [Full text of this article]

Seena Fazel, BMChB, MRCPsych

University of Oxford, Warneford Hospital
Oxford, UK