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Review: several drugs, especially triptans, are effective for pain relief in acute migraine

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Data sources
Studies in any language were identified by searching Medline (1966–2000), EMBASE/Excerpta Medica (1980–2000), the Cochrane Library, and the Oxford Pain Relief Database. Pfizer Inc. was contacted for data on all randomised controlled trials (RCTs) of eletriptan.

Study selection
Studies were selected if they were double-blind, placebo-controlled RCTs of pharmacological treatment for acute migraine (International Headache Society diagnostic criteria for migraine with or without aura) in adults. Other inclusion criteria were single migraine attack, single-dose treatment at standard doses, baseline pain of moderate or severe intensity, and dichotomous or percentage data for 1 efficacy outcome.

Data extraction
Studies were read independently by 2 reviewers and assigned a quality score. Data were extracted on study design, number of patients, dosing regimens, and timing or type of rescue medication. Outcomes were headache relief at 1 and 2 hours, freedom from pain at 2 hours, sustained relief for 24 hours, freedom from pain for 24 hours, and adverse . . . [Full text of this article]

Elizabeth Loder, MD

Harvard Medical School, Boston, Massachusetts, USA