HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Howden, C. W Search for Related Content PubMed Articles by Howden, C. W

Lansoprazole reduced recurrence of ulcer complications in long term use of low dose aspirin

Key Words: aspirin • omeprazole • peptic ulcer • Helicobacter pylori

The first 150 words of the full text of this article appear below.

Design
Randomised {allocation concealed^*}, blinded (clinicians, patients, outcome assessors, monitoring committee, and data analysts),^* placebo controlled trial with a median follow up of 12 months.

Setting
A university hospital in Hong Kong, China.

Patients
123 patients who were 18–80 years of age (mean age 70 y, 72% men) and had ulcers (gastric, duodenal, or gastroduodenal), were receiving low dose aspirin for >1 month before developing ulcers, had a disease such as stroke or ischaemic heart disease that required long term continuous treatment with low dose aspirin, and had H pylori infection that was objectively diagnosed. Exclusion criteria included oesophagitis; a history of gastric or duodenal surgery other than oversewing of a perforation; allergy to study drugs; H pylori infection that could not be eradicated after 2 attempts with eradication therapies; and concomitant treatment with nonsteroidal anti-inflammatory drugs, corticosteroids, or anticoagulants. Follow up was 92%.

Intervention
After healing of the ulcers and eradication . . . [Full text of this article]

Colin W Howden, MD

Northwestern University Feinberg School of Medicine
Chicago, Illinois, USA