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Evidence-Based Medicine 2003; 8:80
© 2003 BMJ Publishing Group


Therapeutics

Training in flexible intensive insulin management improved glycaemic control and quality of life in type 1 diabetes

Training in flexible, intensive insulin management to enable dietary freedom in people with type 1 diabetes: dose adjustment for normal eating (DAFNE) randomised controlled trial. BMJ 2002;325:746–9.[Abstract/Free Full Text]

QUESTION: Does training in flexible intensive insulin management (combining dietary freedom and insulin adjustment) improve glycaemic control and quality of life in patients with type 1 diabetes?

Key Words: diabetes mellitus (insulin-dependent) • insulin • diet • patient education

The first 150 words of the full text of this article appear below.

Design
Randomised (allocation concealed*), unblinded,* wait list controlled trial with follow up at 6 months (Dose Adjustment for Normal Eating [DAFNE]).

Setting
3 hospital diabetes clinics in Sheffield, Northumbria, and London, UK.

Patients
169 patients >18 years of age with clinical features of type 1 diabetes, moderate or poor glycaemic control (glycated haemoglobin [HbA1c] 7.5–12%), and duration of diabetes >2 years without advanced complications. Exclusion criteria were inability to understand English, severe psychiatric illness, pregnancy, and unawareness of hypoglycaemia. 136 patients (80%) completed baseline and 6 month assessments (mean age 40 y, 56% women).

Intervention
84 patients were allocated to the intervention, which comprised a 5 day skills course delivered by 2–3 educators (diabetes specialist nurses or dieticians) to groups of 6–8 participants in each centre. Patients were taught the skills to adjust their insulin by matching it to the desired carbohydrate intake at each meal (rather than adjusting the timing and . . . [Full text of this article]

Arthur T Evans, MD, MPH, Rasa Kazlauskaite, MD

Cook County Hospital and Rush Medical College
Chicago, Illinois, USA







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