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Long term mortality and cardiovascular morbidity increased in some patients with asymptomatic mitral valve prolapse

Key Words: cardiovascular disease • disease free survival • mitral valve prolapse

The first 150 words of the full text of this article appear below.

Design
Inception cohort followed for a median of 5.4 years.

Setting
Olmsted County, Minnesota, USA.

Patients
833 patients (median age 47 y) with a first diagnosis of asymptomatic MVP, first suspected by auscultatory findings (n=557) or found incidentally (n=276), confirmed by echocardiography, who were residents of Olmsted County, Minnesota, USA for 1 year before diagnosis. Exclusion criteria were notable dyspnoea, angina, or mitral surgery before diagnosis. Follow up was 97%.

Assessment of prognostic factors
Clinical and echocardiographic variables. The degree of mitral regurgitation (MR) was stratified into 3 categories: absent or trivial, slight, and moderate to severe.

Main outcome measures
Total mortality, cardiovascular (CV) mortality, and CV morbidity.

Main results
At median follow up of 5.4 years, 96 deaths (11.5%) occurred and 171 patients (20.5%) had CV morbidity. At 10 years, total mortality was 19%, CV mortality was 9%, and CV morbidity was 30%. After adjusting for age, sex, and comorbid conditions, moderate to severe MR and ejection fraction < 50% were . . . [Full text of this article]

Brigitta C Brott, MD

University of Alabama at Birmingham
Birmingham, Alabama, USA