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Review: ophthalmic non-steroidal anti-inflammatory drugs reduce pain without delaying healing in acute corneal abrasions

Key Words: anti-inflammatory agents (non-steroidal) • eye injuries • pain

The first 150 words of the full text of this article appear below.

Data sources
Studies were identified by searching Medline (1966 to April 2002), the Cochrane Database of Systematic Reviews, ACP Journal Club, DARE, and the Cochrane Controlled Trials Registry and by reviewing bibliographies of relevant articles.

Study selection
Studies were selected if they were randomised controlled trials (RCTs) that compared ophthalmic NSAIDs with placebo, oral analgesic, or standard therapy in patients with acute corneal abrasions.

Data extraction
Data were extracted on sample size, study setting and quality, details of the intervention, and outcomes. The main outcomes included pain intensity (visual analogue scale or Numeric Pain Intensity Scale score) and time to healing.

Main results
5 RCTs (397 patients) met the selection criteria. Comparisons included ketorolac 0.5% with a "control vehicle" (1 RCT) or liquifilm tears (1 RCT), diclofenac 0.1% with normal saline solution (1 RCT) or natural tears (1 RCT), and indomethacin 0.1% plus gentamycin sulphate with gentamycin sulphate only (1 RCT). Reduction in pain intensity was greater in . . . [Full text of this article]

Peter Wyer, MD, FACEP

New York Presbyterian Hospital
New York, New York, USA